John is an Assistant Professor in the Center for Translational Medicine and Department of Pharmacology at the Lewis Katz School of Medicine at Temple University. John received his Ph.D. from the Albert Einstein College of Medicine where he published seminal work on the cytoprotective mechanisms of hydrogen sulfide in the lab of Dr. David Lefer. He then trained in molecular biology under Howard Hughes Investigator, Dr. Jeff Molkentin, at Cincinnati Children's Hospital as an NIH-funded postdoctoral fellow. In Cincinnati, John published work detailing a physiological function for the mitochondrial permeability transition pore using various mouse genetic models. During his fellowship he was central in establishing a high-throughput screening facility and also developed new mutant mouse models to study the mitochondrial calcium microdomain. His current research is focused on understanding the molecular regulation of mitochondrial calcium exchange in disease and he continues to search for new genes and pathways involved in necrotic cell death with a therapeutic focus on myocardial infarction and heart failure.